ENIGMA task-based fMRI Working Group (ENIGMA-tbfMRI)

Functional brain imaging of patients and healthy control are important endophenotypes for characterizing psychiatric disorders. In ENIGMA, structural, DTI and resting state fMRI data have been investigated so far. In this working group, we aim to perform large-scale multi-site analyses with task-based fMRI data, i.e. fMRI during the performance of cognitive or affective tasks, in samples with genetic information.

To harmonize data analysis, we have established an easy-to-implement (docker/singularity) and-easy-to-use, semi-automated pipeline for data analysis and quality control based on fMRI prep. This pipeline is suited for distributed analyses and includes no sharing of raw data but only of statistical maps (contrast images) for meta-analyses.

In a first phase we will focus on of three different neurocognitive domains and (variants) of widely used tasks aiming for sample sizes of up to n=10,000.

  • Emotional face processing, operationalized e.g. contrasting emotional faces with neutral stimuli.
  • Reward, operationalized with e.g. variants of the MIED (monetary incentive delay task).
  • Working memory, operationalized with e.g. the N-back or Sternberg task.

We have already established collaboration with labs world-wide and are actively looking for new collaborators. Please contact us if you are interested to be part of ENIGMA tbfMRI and have samples (n>50) with variants of these tasks together with genotype data and are interested in taking part. We are also interested in twin data to estimate heritability of the tasks, as well as repeated measures tb-fMRI data to estimate reliability.

Although this working group will focus first on imaging genetics within these domains, please do not hesitate to contact us if you have data sets for variants of these tasks without genotypes in healthy controls or patients!

Working Group Leaders

Henrik Walter, Ilya Veer and Susanne Erk
Division of Mind and Brain Research
Dept. of Psychiatry and Psychotherapy
Charité – Universitätsmedizin Berlin


To contact us, please email (use “ENGIMA tbfMRI” in the subject heading): susanne.erk@charite.de.
The ENIGMA tbfMRI MoU will be posted here soon.

ENIGMA on social media: