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The ENIGMA Major Depressive Disorder (MDD) Working Group is an international collaboration currently including 40 research samples from 14 different countries worldwide, including brain scans from around >5,000 MDD patients and >9,000 controls. The primary aim of our ENIGMA-MDD Working Group is to identify imaging markers that robustly discriminate MDD patients from healthy controls across many different samples using carefully a priori planned, standardized image processing and statistical analysis protocols. The ENIGMA MDD Working Group is led by A/Prof Lianne Schmaal (chair), Prof Dick Veltman (co-chair) and Elena Pozzi (coordinator).

A list of participating groups (updated May 2020) can be found here.

Click here to access our members page.

We are happy to welcome new cohorts at any time!

If you would like more information and/or are interested in participating, please contact A/Prof Lianne Schmaal and Dr Elena Pozzi



Currently ongoing ENIGMA-MDD projects and the lead person on each one are as follows:


Current MDD member sites are illustrated below:

ENIGMA on social media: