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The ENIGMA Major Depressive Disorder (MDD) Working Group is an international collaboration currently including 40 research samples from 14 different countries worldwide, including brain scans from around >5,000 MDD patients and >9,000 controls. The primary aim of our ENIGMA-MDD Working Group is to identify imaging markers that robustly discriminate MDD patients from healthy controls across many different samples using carefully a priori planned, standardized image processing and statistical analysis protocols. The ENIGMA MDD Working Group is led by A/Prof Lianne Schmaal (chair), Prof Dick Veltman (co-chair) and Elena Pozzi (coordinator).

A list of participating groups (updated May 2020) can be found here.

Click here to access our members page.

We are happy to welcome new cohorts at any time!

If you would like more information and/or are interested in participating, please contact A/Prof Lianne Schmaal and Dr Elena Pozzi

 

Publications:

  • Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group (Schmaal et al. 2016 in Molecular Psychiatry), click here for a copy of the article.
  • Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group (Schmaal et al. 2016b in Molecular Psychiatry), click here for a copy of the article.
  • Childhood adversity impacts on brain subcortical structures relevant to depression (Frodl et al. 2017 in Journal of Psychiatric Research), click here for a copy of the article.
  • Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group (Rentería et al. 2017 in Translational Psychiatry), click here for a copy of the article.
  • Interactive impact of severity of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort (Tozzi et al., 2019 in Psychological Medicine), click here for a copy of the article.
  • White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group (van Velzen et al. 2019 in Molecular Psychiatry), click here for a copy of the article.
  • No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis (de Kovel et al., 2019 in American Journal of Psychiatry), click here for a copy of the article.
  • Classification of Major Depressive Disorder via Multi-Site Weighted LASSO Model (Zhu et al., 2017), click here for a copy of the article on arxiv.
  • Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group (Han et al., 2019), click here for a copy of the article on bioRxiv.
  • Subcortical Shape Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group (Ho et al., 2019), click here for a copy of the article on bioRxiv.
  • Brain Structural Correlates of Insomnia Severity in 1053 Individuals with Major Depressive Disorder: Results from the ENIGMA MDD Working Group (Leerssen et al., 2020 in Translational Psychiatry), click here for a copy of the article.
  • Brain Structural Abnormalities in Obesity: Relation to Age, Genetic Risk, and Common Psychiatric Disorders (Opel et al., 2021 in Molecular Psychiatry), click here for a copy of the article.
  • Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts (Campos et al. 2017 in Biological Psychiatry), click here for a copy of the article.

Currently ongoing ENIGMA-MDD projects and the lead person on each one are as follows:

 

Current MDD member sites are illustrated below:

ENIGMA on social media: