ENIGMA-Tourette Syndrome Working Group

Cordinator: Peristera Paschou, Dept of Biological Sciences, Purdue University, USA.

The ENIGMA-TS working group aims to bring together Tourette Syndrome (TS) research groups in order to share neuroimaging and genetic databases towards large scale studies on brain structure, neurophysiology and the molecular underpinnings of TS. We aim to identify brain regions and brain circuits that are involved in the neurobiology of TS and investigate how these relate to genomic background. Through large-scale analysis of neuroimaging data we will seek to define heritable sub-phenotypes in TS and probe genomic variation in order to dissect the complex genetic architecture of the disorder. In collaboration with other ENIGMA working groups we are working on cross-disorder comparisons with a special focus on neurodevelopmental disorders including OCD, ADHD, and autism.

The working group is motivated by and based on existing large-scale collaborative efforts aiming to understand the etiology of TS, including ESSTS (the European Society for the Study of Tourette Syndrome), TS-EUROTRAIN (a Marie Curie Initial Training Network), and EMTICS (European Multicentre Tics in Children Study).

Currently, investigators from 22 different sites and 11 different countries are working together as part of ENIGMA-TS. As a first goal we are analysing T1-weighted brain MRI data from multiple sites in order to shed light into the pathophysiology of TS. We aim to reach a sample of 1,000 patients with TS.

By joining forces with investigators around the world, sharing expertise and resources in large-scale collaborative efforts like the one represented by ENIGMA-TS we hope to be able to elucidate the etiology of TS and identify targets for the development of new therapies for TS.

Our call for participation is open and we look forward to welcoming new partners! Please join us if you have existing imaging data on TS patients and controls or if you are planning to start such a study. For more information, please contact Dr Peristera Paschou at ppaschou@purdue.edu.

Click here to download our flyer!


ENIGMA-TS Pipelines

Our ENIGMA pipelines to analyze structural brain MRI data (cortical and subcortical segmentation and quality control using FreeSurfer versions 6 and 7) are freely available at the Paschou lab github.





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