Hibar DP, Stein JL, Renteria M, Arias-Vasquez A, Desrivières S et al. Common genetic variants influence human subcortical brain structures, Nature 2015

ENIGMA site-level quality assurance measures

  • All Site Level MDS Plots The first and second principal components of the multidimensional scaling are plotted against each other for each cohort.
  • All Site Level Histograms Histogram plots for each site are shown for the distribution of 1) each structure's left volume, right volume and asymmetry (left volume – right volume)/(left volume + right volume). Structures include: accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus and a volume histogram of ICV. Volumes are shown in cm3 (or mm3 if the scale is in the thousands).
  • All Site Level Manhattan Plots Manhattan plots showing genome-wide association results from each Discovery Part 1 and Discovery Part 2 cohorts for each subcortical structure (accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus) volume and ICV.
  • All Site Level QQ Plots Quantile-Quantile (QQ) plots showing genome-wide association results from each Discovery Part 1 and Discovery Part 2 cohorts for each subcortical structure (accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus) volume and ICV.
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