ENIGMA Brain Injury

The ENIGMA Brain Injury group was formed in Fall of 2016. The Brain Injury group is led by Drs. David Tate (David.Tate@hsc.utah.edu), Lisa Wilde (Elisabeth.wilde@hsc.utah.edu), and Emily Dennis (emily.dennis@hsc.utah.edu).
 

Emily Dennis, PhD. Co-Lead Investigator for the ENIGMA Brain Injury Working Group.
Dr. Dennis is an Assistant Professor of Neurology at the University of Utah. She completed her Neuroscience PhD at the University of California, Los Angeles in 2013 focusing on structural connectivity across development with Dr. Paul Thompson. She completed postdocs at the University of Southern California and Brigham & Women’s Hospital. Her work focuses on the effects of traumatic brain injury on brain structure and function and aims to better understand sources of variability in post-injury outcome. Along with Drs. Tate and Wilde, Dr. Dennis is a co-PI of the Brain Injury working group of the ENIGMA consortium (Enhancing NeuroImaging Genetics through Meta-Analysis). The ENIGMA Brain Injury working group currently has over 170 researchers from 13 countries involved across 10 different subgroups. Click here for Dr. Dennis’ website.
 
 
 
Elisabeth Wilde, PhD. Co-Lead Investigator for the ENIGMA Brain Injury Working Group.
Dr. Elisabeth Wilde is an Associate Professor in the Department of Neurology at the University of Utah. She also holds an appointment as a Health Research Scientist at the VA Salt Lake City Healthcare System. Her research interests include the use of advanced forms of neuroimaging to enhance diagnosis and prognosis, monitor recovery and neurodegeneration, evaluate the efficacy of therapeutic intervention, and elucidate aspects of neuroplasticity in traumatic brain injury. As a clinical neuropsychologist, she has an interest in brain-behavior relationships involving cognitive, neurological, and functional outcome and clinical trials in traumatic brain injury and associated comorbidities. For the last 20 years, she has worked with patients with traumatic brain injury and concussion across a spectrum of age, severity, and acuity, with particular interests in children and adolescents, athletes, and Veteran and Active Duty Service Members with concussion or traumatic brain injury. She has participated in over 40 federally-funded clinical projects in TBI, and has authored over 140 peer-reviewed publications. Dr. Wilde is currently the Director of the Neuroimaging Core for the Department of Defense and Veterans Affairs co-funded Long-term Impact of Military-relevant Brain Injury Consortium (LIMBIC)/Chronic Effects of Neurotrauma Consortium (CENC) Neuroimaging Core and has been actively involved in the International Common Data Elements (CDE) initiative and co-leads the Enhancing Neuroimaging Genetics Meta-analysis (ENIGMA) Working Group for TBI. Click here for Dr. Wilde’s website.
 
 
David Tate, PhD. Co-Lead Investigator for the ENIGMA Brain Injury Working Group.
Dr. David Tate is a clinical neuropsychologist trained at Brigham Young University and Brown Medical School. He is heavily involved in medical imaging research used to examine a number of developmental, clinical, and medical disorders, especially traumatic brain injury. Dr. Tate has held faculty appointments at Brown University, Harvard Medical School, and University of Missouri-St. Louis. Dr. Tate has an active funded research program that explores the biological and cognitive benefits of cognitive rehabilitation treatments for service members with a traumatic brain injury. He also supports the Neuroimaging Core for the Chronic Effects of Neurotrauma Consortium (CENC) which is a multicenter DoD/VA funded collaborative effort to study the long-term effects of mild traumatic brain injury among US service members and veterans. In addition, he has begun working with researchers examining the imaging and cognitive effects high altitude flying has on pilots working in decompressed environments. Click here for Dr. Tate’s website.
 
 
 
Within the Brain Injury groups, we have established sub-groups based on patient type and injury characteristics. These are:

 
All groups are currently recruiting, so if you are interested in participating in any, please email the PIs listed, or Dr. Emily Dennis (emily.dennis@hsc.utah.edu).

Open postdoc positions
Prof. Andrei Irimia, USC

Our memorandum of understanding (ENIGMA_MOU_BrainInjury) lays out guidelines for participation, including questions of authorship and secondary analyses
Members of the working group can propose secondary analyses to the group using forms that can be found on the individual group pages. Once completed please return to the subgroup PIs (listed on form) and David Tate (David.Tate@hsc.utah.edu), Lisa Wilde (Elisabeth.wilde@hsc.utah.edu), and Emily Dennis (emily.dennis@hsc.utah.edu)
 

Talks by ENIGMA Brain Injury and subgroup PIs

Here is a list of abstracts, talks, and publications from the ENIGMA Brain Injury subgroups:

 
PEER-REVIEWED ARTICLES

  1. Wilde EA, Dennis EL, Tate DF (2020) The ENIGMA Brain Injury Working Group: Approach, Challenges, and Potential Benefits. Brain Imaging and Behavior (Special Issue on ENIGMA Brain Injury). (link: https://link.springer.com/article/10.1007/s11682-021-00450-7 )
  2. Tate DF, Dennis EL, Adams JT, Adamson MM, Belanger HG, Bigler ED, Bouchard HC, Clark AL, Delano-Wood LM, Disner SG, Eapen BC, Franz CE, Geuze E, Goodrich-Hunsaker NJ, Han K, Hayes JP, Hinds II SR, Hodges CB, Hovenden ES, Irimia A, Kenney K, Koerte IK, Kremen WS, Levin HS, Lindsey HM, Morey RA, Newsome MR, Pugh MJ, Scheibel RS, Shenton ME, Sullivan DR, Taylor BA, Troyanskaya M, Velez C, Wang X, Ware AL, Zafonte R, Thompson PM, Wilde EA (2020) Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Potential, Challenges, and Harmonization Guidelines from the ENIGMA Military Brain Injury Group. Brain Imaging and Behavior (Special Issue on ENIGMA Brain Injury). (link: https://link.springer.com/article/10.1007/s11682-020-00423-2)
  3. Esopenko C, Meyer J, Wilde EA, Marshall A, Tate DF, Lin A, Koerte IK, Werner KB, Dennis EL, Ware AL, de Souza NL, Menefee DS, Dams-O’Connor K, Stein DJ, Hillary FG (2020) A global collaboration to study intimate partner violence-related head trauma: The ENIGMA consortium IPV working group. Brain Imaging and Behavior (Special Issue on ENIGMA Brain Injury). (link: https://link.springer.com/article/10.1007/s11682-020-00417-0)
  4. Dennis EL, Caeyenberghs K, Asarnow RF, Babikian T, Bartnik-Olson B, Bigler ED, Figaji A, Giza CC, Goodrich-Hunsaker NJ, Hodges CB, Hoskinson K, Levin H, Lindsey H, Livny A, Max JE, Merkley T, Newsome M, Olsen A, Ryan NP, Spruiell MS, Suskauer SJ, Thomopoulos S, Ware AL, Watson CG, Wheeler AL, Yeates KO, Zielinski BA, Thompson PM, Tate DF, Wilde EA (2020) Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group. Brain Imaging and Behavior (Special Issue on ENIGMA Brain Injury). (link: https://link.springer.com/article/10.1007/s11682-020-00363-x)
  5. Koerte IK, Esopenko C, Hinds II SR, Bonke E, Bazarian JJ, Bickart KC, Bigler ED, Bouix S, Buckley TA, Choe MC, Echlin PS, Gill J, Giza CC, Hayes J, Hodges CB, Irimia A, Johnson PK, Kenney K, Levin HS, Lin A, Lindsey HM, Lipton M, Max JE, Mayer AR, Meier TB, Merchant-Borna K, Merkley T, Mills BD, Newsome MR, Porfido T, Shenton ME, Stephens JA, Tartaglia MC, Ware AL, Zafonte RD, Zeineh MM, Thompson PM, Tate DF, Dennis EL, Wilde EA, Baron D (2020). The ENIGMA Sports Injury Working Group – an International Collaboration to Further our Understanding of Sport-Related Brain Injury. Brain Imaging and Behavior (Special Issue on ENIGMA Brain Injury). (link: https://link.springer.com/article/10.1007/s11682-020-00370-y)
  6. Olsen A, Babikian T, Bigler E, Caeyenberghs K, Conde V, Dams-O’Connor K, Dobryakova E, Genova H, Grafman J, Håberg AK, Heggland I, Hellstrøm T, Hodges CB, Irimia A, Jha RM, Johnson PK, Koliatsos VE, Levin H, Li LM, Lindsey HM, Livny A, Løvstad M, Medaglia J, Menon D, Mondello S, Monti MM, Newcombe VFJ, Petroni A, Ponsford J, Sharp D, Spitz G, Westlye LT, Thompson PM, Dennis EL, Tate DF, Wilde EA, Hillary FG (2020). Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group. Brain Imaging and Behavior (Special Issue on ENIGMA Brain Injury). (link: https://link.springer.com/article/10.1007/s11682-020-00313-7)
  7. Bartnik-Olson B, Alger J, Babikian T, Harris A, Holshouser B, Kirov I, Maudsley A, Thompson PM, Dennis EL, Tate DF, Wilde EA, Lin A (2020) The Clinical Utility of Magnetic Resonance Spectroscopy in Traumatic Brain Injury: Recommendations from the ENIGMA MRS Working Group. Brain Imaging and Behavior (Special Issue on ENIGMA Brain Injury). (link: https://link.springer.com/article/10.1007/s11682-020-00330-6)
  8. Dennis EL, Baron D, Bartnik-Olson B, Caeyenberghs K, Esopenko C, Hillary FG, Kenney K, Koerte IK, Lin AP, Mayer AR, Mondello S, Olsen A, Thompson PM, Tate DF, Wilde EA. (2020). ENIGMA Brain Injury: Framework, Challenges, and Opportunities. Human Brain Mapping (Special Issue on ENIGMA). (link: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24998)

PEER-REVIEWED CONFERENCE PAPERS

  1. Dennis EL, Caeyenberghs K, Babikian T, Olsen A, Giza CC, Asarnow RF, Levin H, Kochunov P, Jahanshad N, Thompson PM, Tate D, Wilde E (2018). ENIGMA Pediatric msTBI: Preliminary Results from Meta-Analysis of Diffusion MRI. In: 14th International Symposium on Medical Information Processing and Analysis (SIPAIM 2018), (peer reviewed conference paper). (link: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10975/109750P/ENIGMA-pediatric-msTBI–preliminary-results-from-meta-analysis-of/10.1117/12.2506711.short)
  2. Dennis EL, Wilde EA, Newsome MR, Scheibel RS, Troyanskaya M, Velez C, Wade BSC, Drennon A, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Levin HS, Hinds SR, Walker WC, Thompson PM, Tate DF (2018). ENIGMA Military Brain Injury: A Coordinated Meta-Analysis of Diffusion MRI from Multiple Cohorts. Proc 15th ISBI, Washington D.C., 1386-1389.(peer reviewed conference paper). (link: https://www.ncbi.nlm.nih.gov/pubmed/30034577 )

CONFERENCE TALKS, LECTURES, and WORKSHOPS

  1. White Matter Disruption after Pediatric Moderate/Severe TBI: Results from the ENIGMA Pediatric msTBI Working Group. International Neurotrauma Society, Feb 2021. Virtual.
  2. Advanced Neuroimaging in Pediatric TBI. International Child Neurology Congress/Child Neurology Society Meeting, Oct 2020. Virtual.
  3. Collaborative Approaches to Advance Neuroimaging in Traumatic Brain Injury. University of Utah Neurology Grand Rounds, July 2020: Salt Lake City, UT.
  4. ENIGMA Brain Injury: Framework and Preliminary Results. National Capital Area TBI Research Symposium, March 2020: Bethesda, MD.
  5. Collaborative Approaches to Advance Neuroimaging in Traumatic Brain Injury. UCLA Neurology Grand Rounds, February 2020: Los Angeles, CA.
  6. Big Data Collaborations: First Results from the ENIGMA Brain Injury Working Groups. Frontiers in TBI, September 2019: London, UK.
  7. ENIGMA, An International Consortium on Imaging in TBI. Traumatic Brain Injury Symposium, July 2019: Center for Advanced Studies, LMU Munich, Germany.
  8. ENIGMA Brain Injury: Framework and Preliminary Results. Society for Brain Mapping and Therapeutics, March 2019: Los Angeles, CA.
  9. Big Data Approaches to Neuroimaging in Traumatic Brain Injury. Society for Brain Mapping and Therapeutics, March 2019: Los Angeles, CA.
  10. Altered Subcortical Volume in Chronic TBI Revealed by Mega-Analysis: Results from the ENIGMA Military Brain Injury Working Group. The 13thWorld Congress on Brain Injury, March 2019: Toronto, Canada.
  11. ENIGMA Brain Injury: Global Framework and Preliminary Results. Lecture at the Norwegian University of Science and Technology, December 2018: Trondheim, Norway.
  12. ENIGMA Brain Injury: Global Framework and Preliminary Results. Lecture for the DVBIC/Polytrauma Research Group, October 2018: Palo Alto, CA.
  13. The Search for Neuroimaging Biomarkers of Traumatic Brain Injury. Lecture at the Norwegian University of Science and Technology, November 2017: Trondheim, Norway.
  14. The ENIGMA Consortium: Progress and Applications to Brain Injury Research. International Initiative For Traumatic Brain Injury Research (InTBIR), October 2017: Bethesda, MD.
  15. Imaging Biomarkers of Recovery after Traumatic Brain Injury: The Need for Consortium Studies. Lecture at the Lithuanian University of Health Sciences, October 2017: Kaunas, Lithuania.

CONFERENCE ABSTRACTS

  1. Dennis EL, Wilde EA, Velez C, Troyanskaya M, Haswell C, Bouchard H, Newsome MR, Scheibel RS, Zavaliangos-Petropulu A, Wade BSC, Drennon AM, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Disner S, Franz C, Kremen W, Geuze E, Kenney K, Ollinger J, Bonavia G, Morey R, Adamson MM, Kang X, Koerte I, Shenton ME, Levin HS, Hinds SR, Walker WC, Kochunov P, Jahanshad N, Thompson PM, Tate DF (2021). White Matter Diffusion Abnormalities after Military Deployment-Related TBI: Results from the ENIGMA Military Brain Injury Working Group. International Neurotrauma Society: Virtual.
  2. Dennis EL, Caeyenberghs K, Babikian T, Olsen A, Levin H, Giza CC, Asarnow RF, Kochunov P, Jahanshad N, Thompson PM, Tate D, Wilde E (2019). ENIGMA Pediatric msTBI: Preliminary Results from Meta-Analysis of Diffusion MRI. Society for Neuroscience: Chicago, IL.
  3. Dennis EL, Wilde EA, Velez C, Troyanskaya M, Haswell C, Bouchard H, Newsome MR, Scheibel RS, Zavaliangos-Petropulu A, Wade BSC, Drennon AM, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Disner S, Franz C, Kremen W, Geuze E, Kenney K, Ollinger J, Bonavia G, Morey R, Adamson MM, Kang X, Koerte I, Shenton ME, Levin HS, Hinds SR, Walker WC, Kochunov P, Jahanshad N, Thompson PM, Tate DF (2019). ENIGMA Military Brain Injury: DTI Meta-Analysis. Society for Neuroscience: Chicago, IL.
  4. Dennis EL, Caeyenberghs K, Babikian T, Olsen A, Levin H, Giza CC, Asarnow RF, Kochunov P, Jahanshad N, Thompson PM, Tate D, Wilde E (2019). ENIGMA Pediatric Moderate/Severe TBI: Preliminary DTI Analysis. Organization for Human Brain Mapping: Rome, Italy.
  5. Dennis EL, Wilde EA, Velez C, Troyanskaya M, Haswell C, Bouchard H, Newsome MR, Scheibel RS, Zavaliangos-Petropulu A, Wade BSC, Drennon A, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Disner S, Franz C, Kremen W, Geuze E, Kenney K, Ollinger J, Bonavia G, Morey R, Adamson MM, Kang X, Koerte I, Shenton ME, Levin HS, Hinds SR, Walker WC, Kochunov P, Jahanshad N, Thompson PM, Tate DF (2019). ENIGMA Military Brain Injury: DTI Meta-Analysis. Organization for Human Brain Mapping: Rome, Italy.
  6. Dennis EL, Wilde EA, Zavaliangos-Petropulu A, Newsome MR, Scheibel RS, Troyanskaya M, Velez C, Wade BSC, Drennon A, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Morey R, Haswell C, Bouchard H, Adamson MM, Kang X, Koerte I, Shenton ME, Levin HS, Hinds SR, Walker WC, Thompson PM, Tate DF (2019). ENIGMA Military Brain Injury: Altered Subcortical Volume in Chronic TBI Revealed by Mega-Analysis. Annual Meeting of the American Academy of Neurology, Philadelphia, PA.  (link: https://n.neurology.org/content/92/15_Supplement/P2.9-061#)
  7. Dennis EL, Caeyenberghs K, Babikian T, Olsen A, Giza CC, Asarnow RF, Kochunov P, Jahanshad N, Thompson PM, Tate D, Wilde E (2018).ENIGMA Pediatric msTBI: Preliminary Results from Meta-Analysis of Diffusion MRI. Society for Neuroscience: San Diego, CA. (link: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10975/109750P/ENIGMA-pediatric-msTBI–preliminary-results-from-meta-analysis-of/10.1117/12.2506711.short?SSO=1 )
  8. Koerte IK, Dennis EL, Kaufmann D, Hartl E, Bazarian JJ, Merchant Borna K, Buckley T, Echlin P, Wilde EA, Tate DF, Shenton M, Thompson PM, Kochunov P, Jahanshad N, Baron D (2018). ENIGMA Sports-Related Brain Injury: Framework and Preliminary Results from dMRI Meta-Analysis.NeuroTrauma 2018: Toronto.   (link: http://sportconcussionlibrary.com/wp-content/uploads/2018/08/NNS_sportsTBI_poster-1.pdf )
  9. Dennis EL, Caeyenberghs K, Babikian T, Olsen A, Giza CC, Asarnow RF, Kochunov P, Jahanshad N, Thompson PM, Tate D, Wilde E (2018).ENIGMA Pediatric msTBI: Framework and Single Site Results.NeuroTrauma 2018: Toronto.
  10. Dennis EL, Wilde EA, Newsome MR, Scheibel RS, Troyanskaya M, Velez C, Wade BSC, Drennon A, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Levin HS, Hinds SR, Walker WC, Thompson PM, Tate DF (2018). ENIGMA Military Brain Injury: Framework and Preliminary dMRI Meta-Analysis. NeuroTrauma 2018: Toronto.
  11. Dennis EL, Wilde EA, Newsome MR, Scheibel RS, Troyanskaya M, Velez C, Wade BSC, Drennon AM, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Morey R, Haswell C, Levin HS, Hinds II SR, Walker WC, Jahanshad N, Thompson PM, Tate DF (2018). Meta-Analysis of Diffusion MRI in the ENIGMA Military Brain Injury Group: Preliminary Results. Organization for Human Brain Mapping:
  12. Dennis EL, Wilde EA, Scheibel RS, Troyanskaya M, Velez C, Wade BSC, Drennon AM, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Newsome MR, Levin HS, Hinds II SR, Walker WC, Thompson PM, Tate DF (2018). ENIGMA Military Brain Injury: A Preliminary Meta-Analysis of Diffusion MRI Measures. Annual Meeting of the American Academy of Neurology: Los Angeles, CA. Selected as Platform talk, delivered by Wilde EA. (link: https://n.neurology.org/content/90/15_Supplement/S49.006 )
  13. Dennis EL, Wilde EA, Scheibel RS, Troyanskaya M, Velez C, Wade BSC, Drennon AM, York GE, Bigler ED, Abildskov TJ, Taylor BA, Jaramillo CA, Eapen B, Belanger H, Morey R, Haswell C, Newsome MR, Levin HS, Hinds II SR, Walker WC, Thompson PM, Tate DF (2018). Altered White Matter Organization after Military Brain Injury: Preliminary Results from the ENIGMA Military Brain Injury Group.Federal Interagency Conference on Traumatic Brain Injury: Washington DC. Selected as Platform talk, delivered by Tate DF. (link: https://www.archives-pmr.org/article/S0003-9993(18)30942-0/fulltext )

 

 

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