The aim of the ENIGMA-SCT working group is to bring together Schizotypy (SCT) research groups towards large scale meta-analyses of neuroimaging data across many different studies and datasets.

Our call for participation is open and we look forward to welcoming new partners! If you have existing imaging data on healthy participants who completed a validated schizotypy / subclinical psychotic-like experiences questionnaire, if you are planning to start such a study, or if you would like more information, please contact Drs. Gemma Modinos and André Aleman. We are always open to new datasets and collaborators! The only prerequisite is that each participating group must follow the ENIGMA Memorandum Of Understanding (MOU) guidelines.

To get started, you should usually run your dataset through the current ENIGMA Imaging Protocols (found here), and we can help you with that.

As a first goal, we are analysing T1-weighted brain MRI data from multiple sites in order to shed light into the neurobiology of schizotypy, with a focus on meta-analyses of subcortical and cortical volumes, as well as laterality. All further projects will be listed below as they arise.
 
Co-Chairs:

  • Gemma Modinos, Departments of Psychosis Studies and Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK (gemma.modinos@kcl.ac.uk)
  • André Aleman, Department of Neuroscience, University Medical Centre Groningen, Netherlands (a.aleman@umcg.nl)

 

Projects and their status

Published

Publications:

 
Preprints:

 

Ongoing projects

    Cerebellum
    Raymond C.K. Chan
    Institute of Psychology, Chinese Academy of Sciences, China
    "Structural covariances of cerebellar volumes, subcortical volumes and cortical thickness – an ENIGMA consortium meta-analysis"

Supragranullar
Kelly Diederen, Tom Spencer, Brandon Gunasekera
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
"Is supragranular thinning of the brain’s cortex associated with schizotypy? An ENIGMA consortium meta-analysis"

Language
Matthias Kirschner, Werner Surbeck, Philipp Homan
Psychiatric Hospital University of Zurich, Switzerland
"Anatomical integrity within the ventral language stream and semantic processing deficits in schizophrenia spectrum disorders"

White matter social withdrawal
Jessica A. Turner, Jesse T. Edmond, Gemma Modinos
Ohio State University, OH, USA; Georgia State University, GA, United States; King's College London, UK
"White matter and social withdrawal in schizotypy - an ENIGMA consortium meta-analysis”

NeuroMiner
Gemma Modinos, Nikolaos Koutsouleris
King's College London, UK
"Multivariate pattern analysis of brain structure in schizotypy - an ENIGMA consortium study"

ENIGMA Link
Jeggan Tiego
Monash University, Australia
"‘ENIGMA Link’ - Linking Scales with Item Response Theory Yields Novel Insights into the Structural Neurobiological Correlates of Schizotypy "

RVI
Gemma Modinos
King's College London, UK
"Brain network morphometry to inform individual liability in schizotypy"

rsfMRI
Gemma Modinos
King's College London, UK
"Brain network morphometry to inform individual liability in schizotypy"
 

Locations of ENIGMA-Schizotypy Members

ENIGMA on social media: