ENIGMA-BMIX Working Group
We are interested in the interplay between obesity, major psychiatric disorders and the brain. Obesity is disproportionately frequent in people with psychiatric disorders, such as major depression, bipolar disorders and schizophrenia. This has a marked impact on physical health/mortality, but could also affect brain structure and related psychiatric outcomes. Replicated studies have documented associations between obesity and brain structure. Yet, we do not understand the links between obesity and the brain in major psychiatric disorders. Thus, the BMIX working group focuses on this interaction. We will also study the brain correlates of additional measures of metabolic/cardiovascular health; the role of obesitogenic psychiatric medications; incorporate genetic data and invetigate the effects of low BMI.
The group is led by Tomas Hajek, Nils Opel, Scott Mackey and Jennifer Laurent.
Selected papers by group members:
- McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Díaz-Zuluaga AM, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, van Haren NEM, Gestel HV, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompson PM, Hajek T; ENIGMA Bipolar Disorders Working Group. Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Mol Psychiatry. 2021 Apr 16. doi: 10.1038/s41380-021-01098-x. Epub ahead of print. PMID: 33863996.
- Opel N, Thalamuthu A, Milaneschi Y, Grotegerd D, Flint C, Leenings R, Goltermann J, Richter M, Hahn T, Woditsch G, Berger K, Hermesdorf M, McIntosh A, Whalley HC, Harris MA, MacMaster FP, Walter H, Veer IM, Frodl T, Carballedo A, Krug A, Nenadic I, Kircher T, Aleman A, Groenewold NA, Stein DJ, Soares JC, Zunta-Soares GB, Mwangi B, Wu MJ, Walter M, Li M, Harrison BJ, Davey CG, Cullen KR, Klimes-Dougan B, Mueller BA, Sämann PG, Penninx B, Nawijn L, Veltman DJ, Aftanas L, Brak IV, Filimonova EA, Osipov EA, Reneman L, Schrantee A, Grabe HJ, Van der Auwera S, Wittfeld K, Hosten N, Völzke H, Sim K, Gotlib IH, Sacchet MD, Lagopoulos J, Hatton SN, Hickie I, Pozzi E, Thompson PM, Jahanshad N, Schmaal L, Baune BT, Dannlowski U. Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group. Mol Psychiatry. 2020 May 28. doi: 10.1038/s41380-020-0774-9. Epub ahead of print. Erratum in: Mol Psychiatry. 2021 Jun 22;: PMID: 32467648.
- Steegers C, Blok E, Lamballais S, Jaddoe V, Bernardoni F, Vernooij M, van der Ende J, Hillegers M, Micali N, Ehrlich S, Jansen P, Dieleman G, White T. The association between body mass index and brain morphology in children: a population-based study. Brain Struct Funct. 2021 Apr;226(3):787-800. doi: 10.1007/s00429-020-02209-0. Epub 2021 Jan 23. PMID: 33484342; PMCID: PMC7981300.
- McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze L, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Van Gestel H, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen OA, Thompson PM, Hajek T; ENIGMA Bipolar Disorders Working Group. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. Bipolar Disord. 2021 Dec 11. doi: 10.1111/bdi.13172. Epub ahead of print. PMID: 34894200.
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