ENIGMA-Sleep Working Group

We spend a third of our lives in sleep, yet sleep is less frequently studied using imaging techniques than many neurological and psychiatric disorders. Sleep is increasingly found to have far more health impact than what was previously thought. To boost sleep research and to address many important questions about sleep and its disorders we have formed a group for international collaboration in Sleep research within ENIGMA consortium.

The ENIGMA-Sleep Working Group is aimed to explore meta-analyses of a wide range of neuroimaging modalities in physiology of sleep and its disorders. Measures such as cortical thickness, volume of subcortical structures, PET, and task/resting-state fMRI alterations can be correlated with physiological measures often recorded during polysomnography and actigraphy.

The Group is led by Dr. Masoud Tahmasian and Prof. Dr. Kai Spiegelhalder. Previous prospective meta-analysis studies conducted through an international collaboration proved fruitful. We are actively searching for new international collaborations to join ENIGMA-Sleep Working Group. We are always open to new datasets and collaborators. The only prerequisite is that you be willing to follow the ENIGMA MOU guidelines.

We have wide range of expertise, to overcome possible shortcomings in any of the collaborating projects. If you need any help, please let us know.

If you are interested in participating in the ENIGMA-Sleep group, please contact Dr. Tahmasian.
 
 
Links:

• ENIGMA-Sleep MOU guidelines to participate

• ENIGMA-Sleep analysis plan form

 
 
Ongoing projects:

• Brain age prediction in subjects with sleep deprivation based on the ENIGMA-Sleep data.

• Associations between sleep quality, brain morphometry, APOE genotype, and cognitive performance using the ENIGMA-Sleep framework.

• Separating subjects with and without insomnia based on UK-Biobank and ENIGMA-Sleep Working Group.

 
 
ENIGMA-Sleep publications:

• Weihs A, Frenzel S, Bi H, Schiel JE, Afshani M, Bülow R, Ewert R, Fietze I, Hoffstaedter F, Jahanshad N, Khazaie H, Riemann D, Rostampour M, Stubbe B, Thomopoulos SI, Thompson PM, Valk SL, Völzke H, Zarei M, Eickhoff SB, Grabe HJ, Patil KR, Spiegelhalder K, Tahmasian M; Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)-Sleep Working Group. Lack of structural brain alterations associated with insomnia: findings from the ENIGMA-Sleep Working Group. J Sleep Res. 2023 Mar 21:e13884. doi: 10.1111/jsr.13884.

• Tahmasian M, Aleman A, Andreassen OA, Arab Z, Baillet M, Benedetti F, Bresser T, Bright J, Chee MWL, Chylinski D, Cheng W, Deantoni M, Dresler M, Eickhoff SB, Eickhoff CR, Elvsåshagen T, Feng J, Foster-Dingley JC, Ganjgahi H, Grabe HJ, Groenewold NA, Ho TC, Bong Hong S, Houenou J, Irungu B, Jahanshad N, Khazaie H, Kim H, Koshmanova E, Kocevska D, Kochunov P, Lakbila-Kamal O, Leerssen J, Li M, Luik AI, Muto V, Narbutas J, Nilsonne G, O'Callaghan VS, Olsen A, Osorio RS, Poletti S, Poudel G, Reesen JE, Reneman L, Reyt M, Riemann D, Rosenzweig I, Rostampour M, Saberi A, Schiel J, Schmidt C, Schrantee A, Sciberras E, Silk TJ, Sim K, Smevik H, Soares JC, Spiegelhalder K, Stein DJ, Talwar P, Tamm S, Teresi GL, Valk SL, Van Someren E, Vandewalle G, Van Egroo M, Völzke H, Walter M, Wassing R, Weber FD, Weihs A, Westlye LT, Wright MJ, Wu MJ, Zak N, Zarei M. ENIGMA-Sleep: challenges, opportunities, and the road map. Journal of Sleep Research. 2021 Apr 28; e13347.

 
 
Some selected relevant papers:

• Tahmasian M, Samea F, Khazaie H, Zarei Z, Masouleh SK, Hoffstaedter F, Camilleri J, Kochunov P, Yeo BTT, Eickhoff SB, Valk SL. The interrelation of sleep and mental and physical health is anchored in grey-matter neuroanatomy and under genetic control. Communications Biology. 2020; Volume 3, Article number 171.

• Bagherzadeh-Azbari S, Khazaie H, Zarei M, Spiegelhalder K, Walter M, Leerssen J, Van Someren EJW, Sepehry AA, Tahmasian M. Neuroimaging insights into the link between depression and Insomnia: A systematic review. Journal of Affective Disorders, Volume 258, 1 November 2019, Pages 133-143.

• Javaheripour N, Shahdipour N, Noori K, Zarei M, Camilleri JA, Laird AR, Fox PT, Eickhoff SB, Eickhoff CR, Rosenzweig I, Khazaie H, Tahmasian M. Functional brain alterations in acute sleep deprivation: An activation likelihood estimation meta-analysis. Sleep Medicine Reviews, Volume 46, August 2019, Pages 64-73.

• Tahmasian M, Noori K, Samea F, Zarei M, Spiegelhalder K, Eickhoff SB, van Someren E, Khazaie H, Eickhoff CR. A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis. Sleep Medicine Reviews. 2018 Jul 10;advanced online publication.

• Khazaie H, Veronese M, Noori K, Emamian F, Zarei M, Ashkan K, Leschziner GD, Eickhoff CR, Eickhoff SB, Morrell MJ, Osorio RS, Spiegelhalder K, Tahmasian M, Rosenzweig I. Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI. Neuroscience and Biobehavioural Reviews. 2017 Mar 23;77:219-231.

• Tahmasian M, Rosenzweig I, Eickhoff SB, Sepehry AA, Laird AR, Fox PT, Morrell MJ, Khazaie H, Eickhoff CR. The structural and functional neural adaptations in obstructive sleep apnea: an activation likelihood estimation meta-analysis. Neuroscience and Biobehavioural Reviews, 2016 Jun;65:142-56.

Locations of ENIGMA-Sleep Members