Heritability of the shape of subcortical brain structures in the general population
Partial least squares modelling for imaging-genetics in Alzheimer's disease: Plausibility and generalization
Partial least squares can be used to model joint variation between high-dimensional genomic data and high-dimensional brain morphometry. When we look for optimal gene-phenotype component pairs, rather than testing individual gene effects on individual imaging markers, we can detect our genes' effect on the brain more accurately with greater sensitivity.
ENIGMA on social media:
