Claudia Barth NORMENT, University of Oslo, Norway claudia.barth@medisin.uio.no

Stener Nerland Diakonhjemmet Hospital & NORMENT, University of Oslo, Norway stener.nerland@medisin.uio.no

Ingrid Agartz NORMENT, University of Oslo, Norway ingrid.agartz@medisin.uio.no

The ENIGMA-EOP working group has been formed to explore meta-analysis of existing MRI data of early onset psychosis (EOP) in adolescents and healthy adolescent controls.

The objective of this working group is to identify markers that robustly discriminate adolescents with EOP from healthy controls, differentiate among the different EOP syndromes (including early-onset schizophrenia (EOS) and early-onset bipolar (EOBP) spectrum disorders) by studying the genetic and brain neuroanatomical and functional characteristics across ages and different studies and datasets. The goal is to find the pathophysiological correlates of disease and obtain knowledge about how genetic or other risk factors are related with the brain in EOP and characterize the developmental trajectories. The ENIGMA-EOP working group is chaired by Dr. Ingrid Agartz, at NORMENT, University of Oslo, Norway. The work group is open to new datasets and collaborators, and we are actively in search of collaborative datasets for participating in the meta-analysis, or taking independent study responsibility.
 
If you are interested in participating in projects, please contact Dr. Ingrid Agartz (ingrid.agartz@medisin.uio.no) and Dr. Claudia Barth (claudia.barth@medisin.uio.no).
 

See list of current ENIGMA-EOP co-authors here.

 
Publications:

• Subcortical study: Gurholt TP, Lonning V, Nerland S, Jørgensen KN, Haukvik UK, Alloza C, Arango C, Barth C, Bearden CE, Berk M, Bohman H, Dandash O, Díaz-Caneja CM, Edbom CT, van Erp TGM, Fett AJ, Frangou S, Goldstein BI, Grigorian A, Jahanshad N, James AC, Janssen J, Johannessen C, Karlsgodt KH, Kempton MJ, Kochunov P, Krabbendam L, Kyriakopoulos M, Lundberg M, MacIntosh BJ, Rund BR, Smelror RE, Sultan A, Tamnes CK, Thomopoulos SI, Vajdi A, Wedervang-Resell K, Myhre AM, Andreassen OA, Thompson PM, Agartz I; ENIGMA-EOP Working Group. Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium. Hum Brain Mapp. 2022 Jan;43(1):373-384. doi: 10.1002/hbm.25212. Epub 2020 Oct 5. PMID: 33017498; PMCID: PMC8675418.
• DTI study: Barth C, Kelly S, Nerland S, Jahanshad N, Alloza C, Ambrogi S, Andreassen OA, Andreou D, Arango C, Baeza I, Banaj N, Bearden CE, Berk M, Bohman H, Castro-Fornieles J, Chye Y, Crespo-Facorro B, de la Serna E, Díaz-Caneja CM, Gurholt TP, Hegarty CE, James A, Janssen J, Johannessen C, Jönsson EG, Karlsgodt KH, Kochunov P, Lois NG, Lundberg M, Myhre AM, Pascual-Diaz S, Piras F, Smelror RE, Spalletta G, Stokkan TS, Sugranyes G, Suo C, Thomopoulos SI, Tordesillas-Gutiérrez D, Vecchio D, Wedervang-Resell K, Wortinger LA, Thompson PM, Agartz I. In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis. Mol Psychiatry. 2023 Mar;28(3):1159-1169. doi: 10.1038/s41380-022-01901-3. Epub 2022 Dec 12. PMID: 36510004; PMCID: PMC10005938.
• Voxel Based Morphometry study: Si S, Bi A, Yu Z, See C, Kelly S, Ambrogi S, Arango C, Baeza I, Banaj N, Berk M, Castro-Fornieles J, Crespo-Facorro B, Crouse JJ, Díaz-Caneja CM, Fett AK, Fortea A, Frangou S, Goldstein BI, Hickie IB, Janssen J, Kennedy KG, Krabbendam L, Kyriakopoulos M, MacIntosh BJ, Morgado P, Nerland S, Pascual-Diaz S, Picó-Pérez M, Piras F, Rund BR, de la Serna E, Spalletta G, Sugranyes G, Suo C, Tordesillas-Gutiérrez D, Vecchio D, Radua J, McGuire P, Thomopoulos SI, Jahanshad N, Thompson PM, Barth C, Agartz I, James A, Kempton MJ. Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study. Mol Psychiatry. 2024 Jan 10. doi: 10.1038/s41380-023-02343-1. Epub ahead of print. PMID: 38195979.

Ongoing studies:

• Cortical study, led by Stener Nerland and Claudia Barth
• RVI study, led by Peter Kochunov