ENIGMA-Tremor
Background:
Mixed findings between individual neuroimaging studies on tremor underline the disease heterogeneity, the differences in applied methodology and the low statistical power due to small samples (Hopfner et al., 2016). The ENIGMA Consortium has established successful collaborations to overcome these limitations by pooling retrospective MRI and genetics data from various sites worldwide using harmonized protocols, resulting in well-powered analyses with representative samples (Thompson et al., 2020). Building on this experience, we now seek collaborators to establish the ENIGMA-Tremor working group.
Purpose and Working Group Goals:
ENIGMA-Tremor aims to leverage existing neuroimaging and genetics data from cohorts around the world to identify, characterize and explain how brain alterations are linked to tremor symptoms, subtypes and disease progression. More specifically, we aim to:
- Determine how symptoms associated with tremor, such as gait problems, cognitive decline, dystonic posturing and asymmetry, are correlated to structural and functional imaging markers.
- Identify differential and common neuroimaging signatures across subtypes and compared to controls.
- Determine the relationship between brain structure and function and effectiveness of therapeutic interventions (e.g., DBS and FUS).
Chairs:
Max Laansma, Rick Helmich and Arthur Buijink
ENIGMA-TREMOR IS LOOKING FOR NEW MEMBERS!
We are in an early stage of conceptualization and keen to connect with potential collaborators. If interested, please reach out via our expression of interest form. For more information you can contact the working group coordinator Max Laansma (m.laansma@amsterdamumc.nl).
ENIGMA-Tremor Working Group Memorandum of Understanding (MOU): ENIGMA-Tremor Working Group members are asked to sign a short MoU agreement that has been standardized across ENIGMA projects and provides basic framework to protect data privacy, facilitate data sharing, encourage academic productivity, ensure appropriate authorship and publication credit, and implements a system to track and archive data, analyses and publications related to the ENIGMA-Tremor Working Group.
