ENIGMA Brain Injury

The ENIGMA Brain Injury group was formed in Fall of 2016. The Brain Injury group is led by Drs. David Tate (David.Tate@mimh.edu), Lisa Wilde (Elisabeth.wilde@hsc.utah.edu), and Emily Dennis (emily.dennis@ini.usc.edu).

Within the Brain Injury groups, we have established sub-groups based on patient type and injury characteristics. These are:
ENIGMA Military Brain Injury: led by Drs. David Tate (David.Tate@mimh.edu) and Lisa Wilde (Elisabeth.wilde@hsc.utah.edu)
ENIGMA Pediatric Moderate/Severe TBI: led by Drs. Emily Dennis (emily.dennis@ini.usc.edu), Karen Caeyenberghs (Karen.Caeyenberghs@acu.edu.au), and Lisa Wilde (Elisabeth.wilde@hsc.utah.edu)
ENIGMA Sports Concussion: led by Drs. Dave Baron (Dave.Baron@med.usc.edu) and Inga Koerte (ikoerte@bwh.harvard.edu)
ENIGMA Adult Moderate/Severe TBI: currently being formed by Dr. Alexander Olsen (alexander.olsen@ntnu.no)

All groups are currently recruiting, so if you are interested in participating in any, please email the PIs listed, or Dr. Emily Dennis (emily.dennis@ini.usc.edu).

 

Scan parameters for samples included in the Military Brain Injury analyses:

DoD ADNI: (Parameters)

CENC

CETBI

iSCORE: Each participant completed scanning at a 3 Tesla Siemens Verio Syngo scanner, running version MR B17. Sequences included a T1-weighted MP-RAGE and diffusion-weighted imaging (DWI). The volumetric T1-weighted sequence (1 mm3 isotropic voxels) was acquired using a 32-channel head (field of view (FOV), 256 mm; repetition time (TR) = 2300 ms, echo time (TE) = 2.98 ms, flip angle = 9 degrees, and a slice thickness = 1 mm). DWI images were acquired with the following acquisition parameters: TR/TE=12,700/85 ms; FOV=128x128mm; isotropic voxel size=2 mm. 65 images were collected per subject: 1 b0 and 64 diffusion-weighted images (b=1000 s/mm2). All scans were visually inspected for artifacts such as motion or inhomogeneity.

MIRECC: Images were acquired on a GE 3.0 Tesla EXCITE scanner with an 8-channel headcoil. All participants underwent (i) DTI with 2  2  2-mm voxel size automatically resampled to 1  1  2-mm, FOV 240  240-mm, flip angle 90, TR ¼ 17,000-ms, TE ¼ 76-ms, 1 average, 55 noncollinear directions (diffusion gradients), nonzero b-value ¼ 1,000 s/mm2, scanning time ¼ 11-min, and (ii) high resolution T1-weighted 3D-FSPGR images with 1-mm isotropic voxels (TR/TE/flip angle ¼ 7.484-ms/2.984-ms/12, 256-mm FOV, 166 slices, and 1 excitation). All diffusion weighted and T1-weighted images were visually inspected for quality and no scans were rejected.

ENIGMA Military Brain Injury Acknowledgements: ELD is supported by a grant from the NINDS (K99 NS096116). ELD and PT are also supported by NIH grants to PT: U54 EB020403, R01 AG040060, and R01 NS080655. DoD ADNI is supported by the NCIRE (DoD W81XWH-12-2-0012). The Chronic Effects of Neurotrauma Consortium is supported by grants PT108802-SC104835 and W81XWH-13-2-0095 from the Department of Defense and grant 5I01RX002174 from the VA. A Longitudinal Study of Chronic TBI in OEF/OIF/OND Veterans and Service Members is supported by grant funding from the VA (study number O1062-I; grant number: 5I01RX001062). Funding for the iSCORE study was provided by the Defense and Veterans Brain Injury Centers, U.S. Army Medical Research and Materiel Command (USAMRMC; W81XWH-13-2-0025). National Institute for Mental Health Grant No. R01-MH111671-01 and VISN6 MIRECC (to RAM); VA Merit Grant Nos. 1I01RX000389-01 (to RAM) and 1I01CX000748-01A1 (to RAM); National Institute of Neurological Disorders and Stroke Grant Nos. 5R01NS086885-02 and K23 MH073091-01 (to RAM); This material is based in part upon work supported by the U.S. Army Medical Research and Material Command and from the U.S. Department of Veterans Affairs. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. Any opinions, findings, conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the U.S. Government, the U.S. Department of Veterans Affairs, or the U.S. Department of Defense, and no official endorsement should be inferred.

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