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There are currently many ongoing secondary projects, building upon ENIGMA-Epilepsy’s initial investigations of gray matter and white matter microstructure. Each project, and its respective co-leads, is detailed below.

Published projects

Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study, published in Brain 2018
Christopher D. Whelan
University of Southern California, Los Angeles, CA, United States
Sanjay M. Sisodiya and Andre Altmann
University College London, London, UK

White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study, published in Brain 2020
Sean Hatton and Carrie R. McDonald
University of California – San Diego, San Diego, CA, USA

The ENIGMA-Epilepsy working group: Mapping disease from large data sets, published in Human Brain Mapping 2020
Sanjay M. Sisodiya
University College London, London, UK
Carrie R. McDonald
University of California – San Diego, San Diego, CA, USA

Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study, published in Science Advances 2020
Sara Larivière and Boris Bernhardt
McGill University, Montreal, Canada

Ongoing projects

Genetic analyses of brain-wide phenotypes in epilepsy, submitted; preprint posted
Sanjay M. Sisodiya and Andre Altmann
University College London, London, UK
Christopher D. Whelan
University of Southern California, Los Angeles, CA, United States

Structural correlates of drug resistance in epilepsy
Sanjay M. Sisodiya
University College London, London, UK
Christopher D. Whelan
University of Southern California, Los Angeles, CA, United States

Structural correlates of valproic acid assumption in epilepsy
Stefano Meletti
UNIMORE, Modena, Italy

Anatomical predictors of postoperative outcome in temporal lobe epilepsy
Simon Keller
University of Liverpool, Liverpool, UK

Graph analysis of structural covariance in mild mesial temporal lobe epilepsy
Maria Eugenia Caligiuri and Angelo Labate
IBFM-CNR, Catanzaro, Italy
Università Magna Graecia, Catanzaro, Italy

Structural correlates of mild mesial temporal lobe epilepsy with and without hippocampal sclerosis
Maria Eugenia Caligiuri and Angelo Labate
IBFM-CNR, Catanzaro, Italy
Università Magna Graecia, Catanzaro, Italy

Localizing the seizure focus through the use of deep learning applied to structural and diffusion tensor imaging data
Yu-Hsuan A. Chang and Carrie R. McDonald
University of California – San Diego, San Diego, CA, USA

Resting state functional connectivity in patients with TLE
Victoria Ives-Deliperi, Jonathan Ipser and Dan Stein
University of Cape Town, Cape Town, South Africa

Cross-sectional latent profile analysis of neuroanatomical structures within and between common epilepsy syndromes
Dalin T. Pulsipher
Akron Children’s Hospital, Akron, OH, USA

Disease Progression
Andre Altmann
University College London, London, UK

The neuroimaging signature of SUDEP and implications for disease biology
Sanjay Sisodiya
University College London, London, UK

Multimodal disease spectrum learning in the common epilepsies
Boris Bernhardt, Raúl Rodríguez-Cruces and Sara Larivière
McGill University, Montreal, Canada

Structural changes at onset of illnesst
Michael Rebsamen, Christian Rummel and Roland Wiest
University of Bern, Inselspital, Switzerland

Longitudinal Study
Marian Galovic
University Hospital Zurich, Zurich, Switzerland
John S Duncan and Matthias Koepp
University College London, London, UK

Multi-modal MRI markers of pharmacoresistance in GGE
Simon Keller
University of Liverpool, Liverpool, UK

Unsupervised machine learning for epilepsy biotype clustering
Barbara Kreilkamp and Niels Focke
University Medicine Göttingen, Göttingen, Germany

Topological network analysis and graph-based deep learning of multimodal MRI: An ENIGMA-Epilepsy pilot study
Yuan Wang
University of South Carolina, Columbia, SC, USA

Multivariate independent components of abnormality in epilepsy: relation to duration
Peter Taylor and Yujiang Wang
Newcastle University, Newcastle upon Tyne, UK
 
 

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