Welcome to EnigmaVis!
EnigmaVis is a set of tools for generating interactive plots and for accessing genetic similarity between the user uploaded trait and ENIGMA phenotypes.
Contributors: Natalia Shatokhina (developer), Derrek Hibar, Neda Jahanshad, Jason Stein (scientific idea), Nic Novak (initial implementation)
To get begin , make a query using the fields below. Hit “submit” to generate your plot. Additional documentation of features will be displayed below the plot, after it is generated.
EnigmaVis is free to use. If you use the tool, please cite EnigmaVis publication
Search by SNP, Position or Gene:
Step 1)Select phenotypes to plot. Select up to three phenotypes from the tree below.
You may add up to 8 phenotypes by clicking the checkboxes.
Optional: You can use EnigmaVis to plot your own data alongside the results from the ENIGMA consortium. To do this, upload a comma-delimited CSV file containing the data you would like to plot. An example file demonstrating the correct format is provided here. You can upload files up to 2Mb in size. After you choose your file, press “Upload selected file,” and your data will be uploaded and then appear in the phenotype selection dropdown, above. If your data does not appear immediately, please refresh the page.
Step 2)Enter your query in the box below. EnigmaVis will interpret what you want to plot. Example queries are provided in blue below to help get you started. You can search by SNP, position, or gene.
Search by SNP (queries by example):
Search by position (queries by example):
Search by gene (queries by example):
Chart options and features
|Zooming – To zoom in to the plot, simply drag the area you wish to enlarge directly on the plot. A button will appear at the top of the plot, prompting you to zoom.|
The enrichment test feature is added to Enigma-Vis to let the user estimate the genetic similarity between the user uploaded trait and all ENIGMA 2 phenotypes. We use a parrallel implementation of SECA SNP concordance analysis tool coded by Dale R. Nyholt to estimate a pleiotropy and concordance of a pair of traits. The output of the enrichment test is a set of genetic similarity heatmaps. Note: This feature is currently in beta testing, you need to submit a request to process the data.
NEW!! Our recent GWAS of subcortical structures (Hibar et al., 2015) are available for bulk download here